Jane returns to her roots in South Africa to catch Hank Crawford and stop Roman once and for all; Zapata leaves the CIA and puts the brakes on her romance with Reade; the FBI questions Blake .

Jane, Weller and the team must stop Roman from blowing up the United Nations headquarters in New York City in an attempt to assassinate two world leaders.

When Patterson gets a hit on an ultraviolet skull tattoo, the team discovers the assassin who killed Avery's dad; meanwhile, Roman endures troubling hallucinations. Bill Nye guest stars.

The team decodes the beetle tattoo, which leads them to a deadly weapon that was secretly developed for Hank Crawford, and they must find the weapon's engineer before Roman does.

Jane and her team must fight for their lives when Roman sends deadly assassins after them.

The team infiltrates Blake's fundraising gala to stop Crawford and Bruyere from pulling off a terrorist massacre, but things go awry when Roman thwarts the team's plan.