Lester Holt reports on how the investigation into the murder of four-year-old Barbara Jean Horn revealed decades of misconduct across Philadelphia’s criminal justice system.

The Duenas family appears to be perfect, until a tragedy shakes their household, faith and family. Keith Morrison reports.

After a nightclub owner is gunned down in his home, Chicago police discover the death was a targeted killing, connected to a twisted sense of loyalty and tradition. Natalie Morales reports.

When loving mother Lisa Knoefel is stabbed to death in her home outside Cleveland, her family is shattered. Josh Mankiewicz reports.

A circle of friends from a Miami high school are about to embark on a new beginning at college. But one friend surprises them all. Dennis Murphy reports.

A mother's search for answers in her son’s murder raises questions about whether Chicago police detectives did enough to try to solve his case. Josh Mankiewicz reports.