House reluctantly accepts the case of Wilson's cousin, a kindergarten teacher who had a seizure and collapsed while teaching.

When a teenage lacrosse player is stricken with an unidentifiable brain disease, House and the team hustle to give his parents answers.

When a college student collapses after sex, House and his team must figure out why. The doctors offer their diagnoses, but the patient has too many symptoms to add up to just one disease.

When House predicts an epidemic in the maternity ward, the ward is shut down, babies are quarantined and House suggests a plan to sacrifice one baby for the good of the rest.

A nun whose hands are red and swollen is sent to House. He gives her pills which cause her to become unable to breathe. Her sisters pray for her while House has to wonder if he misdiagnosed her.

House's approach is questioned when he treats a nun for what he believes to be an allergy, not realizing the nun's past is coming back to haunt her.