After Wilson threatens to resign, House thinks of anything to keep him at the hospital and keep their friendship alive. Meanwhile, the team treats an assistant who reminds Thirteen of herself.

The team treats an executive assistant with mysterious symptoms; meanwhile, Wilson resigns from Princeton-Plainsboro, and House must determine if he is responsible for Amber's death.

An organ donor's organs are responsible for the deaths of several patients, and the team works to save the last two recipients. Meanwhile, House hires a private detective to keep tabs on Wilson.

When several people die years after receiving transplants from a single organ donor, House and the team rush to save the only two surviving recipients; House hires a private investigator.

A painter's undiagnosed illness affects his work, and House and his team must look at the man's paintings to determine what's wrong with him.

A struggling artist comes down with an undiagnosed illness that's distorting his perception and threatening his career; House continues to have a private investigator dig up dirt on his team.