House and Cuddy explore the ramifications of their feelings for each other; meanwhile, the hospital's only neurosurgeon falls ill, and the team attempts to get their sick colleague back to work.

House and the team take on the case of a seemingly healthy teenager who collapses during a skateboarding exhibition; meanwhile, House and Cuddy take their romantic relationship to work.

When a popular author has a seizure moments before attempting suicide, House takes on the case and looks to her recent novel for clues about her condition; House and Cuddy go on a double date.

The team makes unexpected discoveries about a patient who is admitted to the hospital for severe vomiting; a visit from House's massage therapist tests his relationship with Cuddy.

When a newborn experiences breathing problems and liver failure, House and the team look at the medical history of the baby's mother for possible clues; House babysits Cuddy's daughter.

A politician's campaign manager mysteriously falls ill with liver failure and temporary paralysis; House chooses a third-year medical student to join the team.