As House serves time behind bars, he attempts to solve the mystery behind a fellow inmate's unusual symptoms; meanwhile, a clinic doctor must decide whether to risk her job by helping House.

An unexpected visitor offers House the chance to help the Princeton Plainsboro team with a patient, but once he's back at the hospital, he's forced to work with a smart yet timid resident.

When a man collapses after making a generous donation, House and Park try to identify his medical disorder; meanwhile, House recruits Adams to help with the case.

House and the team must save the life of a businessman who becomes ill days before signing a contract that would relocate his company's labor force to China.

A patient under House's care confesses dark secrets to his family and community, compromising his chances of receiving life-saving medical treatment; meanwhile, Chase and Taub rejoin the team.

The team discovers a disturbing family secret while trying to find a bone marrow match for an ailing teen; House tries to remove his ankle monitor so he can go to a boxing match.