Katherine Heigl plays Charleston Tucker on the NBC drama "State of Affairs."On television for six seasons, Heigl portrayed Dr. Isobel "Izzie" Stevens, the small-town girl constantly battling for respect amongst her peers, on ABC's critically acclaimed drama "Grey's Anatomy." In 2007, Heigl earned an Emmy Award and a Golden Globe nomination for her performance.Previous to "Grey's Anatomy," Heigl had a co-starring role on the WB sci-fi drama series, "Roswell."Heigl starred in Judd Apatow's smash hit comedy, "Knocked Up," followed by a starring turn with Ed Burns and James Marsden in the romantic comedy "27 Dresses." She then starred opposite Gerard Butler in the romantic comedy "The Ugly Truth," which she also executive produced. These roles earned Heigl Female Star of the Year honors at the 2010 ShoWest Awards.

Heigl recently wrapped starring roles in the independent feature films "Your Right Mind," opposite Ben Barnes, and "Jenny's Wedding," with Alexis Bledel and Tom Wilkinson. Heigl was part of an all-star cast, including Will Arnett, Liam Neeson and Brendan Fraser, lending their voices to this January's hit animated comedy feature "The Nut Job."

Additional film credits include "The Big Wedding," "New Year's Eve," "Life as We Know It," "Killers," "The Ringer" and Steven Soderbergh's critically acclaimed depression-era drama "King of the Hill." Her first feature-film leading role was in "My Father the Hero," starring opposite Gerard Depardieu.In 2009, Heigl and her mother, Nancy, launched the Jason Debus Heigl Foundation in honor of her older brother, who died much too young in an automobile accident and whose strong, compassionate nature and great love of animals is the cornerstone of their endeavors. The Heigls are using their resources to work directly to address the pet population crises in Los Angeles and across the country. Toward that goal, the foundation launched the "Compassion Revolution" in 2010, pledging over $1 million to a variety of low-cost and free spay/neuter programs in Los Angeles and surrounding counties as a key component to reducing the number of animals in shelters.The foundation also presently funds pet education programs, actively supports spay/neuter programs, pet adoption programs, and funds and supports small dog transport from local kill shelters to both no-kill shelters and rescue facilities throughout the country. To date the foundation has funded more than 5,500 spay/neuter surgeries, the transport of over 1,400 animals out of high-kill shelters to areas where they are rapidly adopted, and an overwhelming variety of adoption and training programs intently focused on improving the plight of our pets.Heigl also actively supports Donate Life, the organ donation foundation.