Charles and Archer treat a heart transplant patient who believes his new heart doesn't want to be in his body. Lenox takes a personal day. Asher discovers a mass on a pregnant woman's ovary.

A former patient of Goodwin's returns to Med. Frost and Charles treat a patient struggling with his sexuality. Lenox and Abrams work to save a woman who has been in a coma for 20 years.

Ripley struggles to rescue a woman and her daughter trapped in an abandoned well. An old friend from Frost's TV days shadows Maggie. Asher discovers a rare condition in her patient's ultrasound.

Gaffney gets a surprise visit from a National Accreditation Board of Hospitals representative. Asher and Naomi search for the cause of a young girl's infection.

Lenox's mentorship is put to the test. Asher helps a religious young woman with an ectopic pregnancy. Ripley's self-destructive behavior continues to escalate.

Goodwin struggles with the psychological aftermath of her attack. Ripley treats a patient with helicopter parents. An ED staffer makes a mistake that may cost them their job.