La Doña returns to Mexico and must face justice and her enemies. Mónica and Saúl stayed together, with him working as a lawyer at the head of the Renacer Foundation, and she as a law student. Together with her aunt Regina, they fight to eradicate gender violence, but there are always psychopaths like Los Arcoiris, a gang that murders women and leaves them marked with paint bullets. Noelia Molina looks for the culprits because she no longer has faith in the police - until she crosses paths with León Contreras, an agent who changes her mind because of his flawless police career. León links Monica's disappearance to Los Arcoiris, but Altagracia suspects her enemies, although she doesn't know that Braulio Padilla is alive. Altagracia, León and Noelia become a love triangle with the same objective: to find Mónica and avenge the death of her loved ones.