The movie opens with a faulty nanotechnology experiment that results in a massive, deadly explosion. The company's CEO manages to sidestep blame by framing a meddling young reporter, Katherine, who now holds the only surviving evidence needed to expose the truth. All the while, the dangerous nanoparticles - having escaped from the explosion into the stratosphere - threaten to destroy nearby cities with wildly destructive weather patterns. Among the chaos of the storms, and on the run from the authorities, Katherine must - with the help of a young scientist - get the evidence to the government to enlist their help before it's too late... and the deadly disaster turns worldwide.